IFNγ modulates human immunoglobulin receptor expression in lipoaspirate-derived mesenchymal stem cells
نویسندگان
چکیده
Latar belakang: Sel punca mesenkim (MSC) mempunyai kapasitas imunomodulator terhadap penyakit autoimun dan mencegah penolakan imun alogenik. Banyak studi mengungkapkan bahwa MSC menghambat proliferasi sel T dan menginduksi kondisi imunosupresi melalui produksi prostaglandin dan interleukin-10. Pemberian MSC pada pasien autoimun dapat mengurangi autoantibodi di sirkulasi. Sejauh ini belum pernah dilaporkan keberadaan reseptor Fc (reseptor immunoglobulin) pada MSC. Penelitian ini bertujuan untuk mengungkapkan ekspresi reseptor Fcγ (FcγR) pada MSC yang diisolasi dari lipoaspirat dengan mendeteksi mRNA reseptor Fcγ dan menganalisis apakah ekspresinya dapat dimodulasi.
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تاریخ انتشار 2014